Cigarette smoke induces aberrant EGF receptor activation which mediates lung cancer development and resistance to tyrosine kinase inhibitors
نویسندگان
چکیده
Abbreviations used are: ~, about; α, anti-; ∆, delta (deletion); Ab or Abs, antibody or antibodies; Cav-1, caveolin-1; CS, cigarette smoke; EDAC, 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; H2O2, hydrogen peroxide; HAE, human airway epithelial; HRP, horseradish peroxidase; IB, or IBed, immuno-blotting or immuno-blotted; IP or IPed, immuno-precipitation or immuno-precipitated; m, monoclonal; min., minutes; MT or MTs, mutant or mutants; NSCLC non-small cell lung cancer; NT, non treated or untreated; ox-stress, oxidative stress; p-, phosphorylated; SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis; StDevs, standard deviations; TKI or TKIs, tyrosine kinase inhibitor(s); Y or Tyr-, tyrosine; WT, wild type.
منابع مشابه
Therapeutic Discovery Cigarette Smoke Induces Aberrant EGF Receptor Activation That Mediates Lung Cancer Development and Resistance to Tyrosine Kinase Inhibitors
TheEGF receptor (EGFR) and its downstreamsignaling are implicated in lung cancer development. Therefore, much effort was spent in developing specific tyrosine kinase inhibitors (TKI) that bind to the EGFRATP-pocket, blocking EGFR phosphorylation/signaling. Clinical use of TKIs is effective in a subset of lung cancers with mutations in theEGFRkinasedomain, rendering the receptorhighly susceptibl...
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The EGF receptor (EGFR) and its downstream signaling are implicated in lung cancer development. Therefore, much effort was spent in developing specific tyrosine kinase inhibitors (TKI) that bind to the EGFR ATP-pocket, blocking EGFR phosphorylation/signaling. Clinical use of TKIs is effective in a subset of lung cancers with mutations in the EGFR kinase domain, rendering the receptor highly sus...
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